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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Mitochondrial DNA methylation profiling of the human prefrontal cortex and nucleus accumbens: correlations with aging and drug use

Fig. 4

The Drug-using index (DU_index) in the NAcc and the PFC. For the differential methylation levels between the drug use group and the control group, the Manhattan plots show the significance level of each cytosine site across the mitochondrial genome of the NAcc (a) and the PFC (b). The encoded genes are shown at the top of the plots. c, d The volcano plots show the relative methylation level of each cytosine between the drug use group and the control group against the P value in the NAcc (c) and the PFC (d). a–d The cytosine sites above the dashed line (P value = 0.05) were selected for constructing the DU_index, and the color of each dot represents the sequence context. e The box plot shows the distribution of the DU_index scores in different groups and the brain areas. The P values are shown in the plots. PPV: positive predictive value; NPV: negative predictive value. f, g The ROC curves show the general performance of the DU_index in the NAcc (f) and the PFC (g).

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