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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Mitochondrial DNA methylation profiling of the human prefrontal cortex and nucleus accumbens: correlations with aging and drug use

Fig. 3

The mitochondrial epigenetic clock in the NAcc and the PFC. For the correlations between methylation levels and chronological ages, the Manhattan plots shows the significance level of each cytosine site across the mitochondrial genome of the NAcc (a) and the PFC (b). The encoded genes are shown at the top of the plots. In c and d, the volcano plots show the correlations between methylation levels and chronological ages in the NAcc (c) and the PFC (d). a–d The cytosine sites above the dashed line (P value = 0.05) were selected for constructing the Age_index, and the color of each dot represents the sequence context. e The scatter plot shows the correlations between the chronological ages and the predicted ages from the NAcc (○) and the PFC (∆). The blue shade area (NAcc) and the brown shade area (PFC) represent the 95% confidence intervals for the predicted line in each region. The R2 and P value are indicated in the plot. f, g The box plots show the distribution of the accelerated ages in different groups in the NAcc (f) and the PFC (g). The P values are shown in the plots.

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