1st generation of epigenetic clocks | 2nd generation of epigenetic clocks | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
IEAAa | HannumEAAa | PhenoEAAa | GrimEAAa | |||||||||
Beta | 95% CI | p | Beta | 95% CI | p | Beta | 95% CI | p | Beta | 95% CI | p | |
Seven-component CVH scoresb | ||||||||||||
CVH score (2-level, 7-point) | − 0.101 | [− 0.2475, 0.0458] | 0.177 | − 0.122 | [− 0.2709, 0.0269] | 0.108 | − 0.350 | [− 0.5459, − 0.1550] | 4.5E−4 | − 0.499 | [− 0.6222, − 0.3758] | 4.2E−15 |
CVH score (3-level, 14-point) | − 0.074 | [− 0.1670, 0.0194] | 0.120 | − 0.083 | [− 0.1773, 0.0119] | 0.087 | − 0.268 | [− 0.3919, − 0.1439] | 2.4E−5 | − 0.364 | [− 0.4419, − 0.2865] | 1.5E−19 |
Six-component CVH scoresc | ||||||||||||
CVH score (2-level, 6-point) | − 0.086 | [− 0.2093, 0.0366] | 0.169 | − 0.088 | [− 0.2092, 0.0324] | 0.151 | − 0.388 | [− 0.5528, − 0.2238] | 3.9E−6 | − 0.526 | [− 0.6289, − 0.4222] | 6.1E−23 |
CVH score (3-level, 12-point) | − 0.068 | [− 0.1440, 0.0085] | 0.082 | − 0.065 | [− 0.1396, 0.0102] | 0.091 | − 0.278 | [− 0.3798, − 0.1761] | 9.6E−8 | − 0.377 | [− 0.4407, − 0.3136] | 2.1E−30 |