Skip to main content

Table 2 Results of regressing four measures of EAA on the CVH score

From: Cardiovascular health and four epigenetic clocks

 

1st generation of epigenetic clocks

2nd generation of epigenetic clocks

IEAAa

HannumEAAa

PhenoEAAa

GrimEAAa

Beta

95% CI

p

Beta

95% CI

p

Beta

95% CI

p

Beta

95% CI

p

Seven-component CVH scoresb

CVH score (2-level, 7-point)

 − 0.101

[− 0.2475, 0.0458]

0.177

 − 0.122

[− 0.2709, 0.0269]

0.108

 − 0.350

[− 0.5459, − 0.1550]

4.5E−4

 − 0.499

[− 0.6222, − 0.3758]

4.2E−15

CVH score (3-level, 14-point)

 − 0.074

[− 0.1670, 0.0194]

0.120

 − 0.083

[− 0.1773, 0.0119]

0.087

 − 0.268

[− 0.3919, − 0.1439]

2.4E−5

 − 0.364

[− 0.4419, − 0.2865]

1.5E−19

Six-component CVH scoresc

CVH score (2-level, 6-point)

 − 0.086

[− 0.2093, 0.0366]

0.169

 − 0.088

[− 0.2092, 0.0324]

0.151

 − 0.388

[− 0.5528, − 0.2238]

3.9E−6

 − 0.526

[− 0.6289, − 0.4222]

6.1E−23

CVH score (3-level, 12-point)

 − 0.068

[− 0.1440, 0.0085]

0.082

 − 0.065

[− 0.1396, 0.0102]

0.091

 − 0.278

[− 0.3798, − 0.1761]

9.6E−8

 − 0.377

[− 0.4407, − 0.3136]

2.1E−30

  1. aIEAA (i.e., intrinsic EAA), HannumEAA, PhenoEAA, and GrimEAA were calculated according to the four epigenetic clocks: Horvath’s clock [11], Hannum et al.’s clock [10], Levine et al.’s PhenoAge [12], and Lu et al.’s GrimAge [13], respectively
  2. bThe seven-component CVH score was calculated according to the definition of CVH from the American Heart Association (AHA)
  3. cBecause 42% of the 2474 TWB participants were surveyed by the simplified questionnaire without diet information, the six-component CVH score was calculated without the “ideal diet score.” Other components followed the same definition of the CVH score from the AHA