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Table 3 Top five differentially methylated positions for airflow limitation and restrictive pattern lung function

From: An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study

CpG

Chr

Gene

Function

Odds Ratio (95% CI)

p value

Airflow limitation

cg20304857

2

GALNT14

Catalyze transfer of N-acetyl-D-galactosamin to hydroxyl groups on serines and threonines

2.8 (1.9, 4.3)

E−06

cg07842459

1

CD84

Homophilic adhesion molecule

2.8 (1.8, 4.3)

2E−06

cg17916980

16

CPPED1

Serine/Threonine-Protein Phosphatase. Dephosphorylates AKT family kinase

2.5 (1.7, 3.7)

2E−06

cg03647068

2

FMNL2

Morphogenesis, cytokinesis, cell polarity

3.0 (1.9, 4.8)

2E−06

cg06100532

16

LMF1

Involved in the maturation of specific proteins in the endoplasmic reticulum

2.8 (1.8, 4.3)

3E−06

Restrictive pattern

cg05504535

10

ADARB2

Regulatory role in RNA editing

0.3 (0.2, 0.5)

1.86E−07

cg04890495

11

MCAM

Cell adhesion, cohesion of the endothelial monolayer at intercellular junctions in vascular tissue

0.3 (0.2, 0.5)

5.92E−07

cg03320255

19

ZNF540

Transcriptional repressor

0.3 (0.2, 0.5)

8.72E−07

cg20024687

8

TOP1MT

Role in the modification of DNA topology

0.4 (0.2, 0.5)

3.00E−06

cg19693031

1

TXNIP

Protects cells from oxidative stress

0.4 (0.3, 0.6)

4.00E−06

  1. Top five DMPs selected by elastic-net models. Odds Ratios reported from regression models comparing percentile 90 vs percentile 10 of DNA methylation. Models were adjusted for age, squared age, prior tuberculosis diagnosis, sex, BMI, smoking status (never, former, current), cumulative smoking (pack-years), study center (Arizona, Oklahoma, or North and South Dakota), cell counts (CD8T, CD4T, NK, B cells and monocytes) and five genetic PCs