Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival

Table 2 Significant covariables in metastasis signature Cox model

Name	UCSC_RefGene_Name	coef	HR	p.adj
age_at_diagnosis	NA	0.130	1.138	0.000
cg00263760	VAX1	1.019	2.771	0.008
cg00478851	PPFIBP2	0.921	2.511	0.040
cg00562312	ADAMTS2	0.817	2.264	0.040
cg00807464	CUX2	1.151	3.160	0.005
cg01607369	PPFIBP2	1.079	2.943	0.010
cg01965173	RIPPLY2	− 2.296	0.101	0.001
cg03818920	RIPPLY2	1.587	4.891	0.031
cg03847279	FGFRL1	1.547	4.697	0.000
cg05632623	NPTX1	− 2.470	0.085	0.004
cg06103654	DPYSL5	1.111	3.036	0.004
cg06385227	EN2	− 1.416	0.243	0.000
cg09619271	IGFBP3	− 0.652	0.521	0.031
cg11317199	TRIM14	− 0.637	0.529	0.031
cg12094808	FRMD5	− 0.760	0.468	0.031
cg12156672	CDK5R2	− 0.922	0.398	0.031
cg12387713	MSX2	0.877	2.404	0.007
cg13058819	SLC35F3	− 1.230	0.292	0.006
cg14002622	CDK5R2	0.833	2.301	0.006
cg15004938	SYN3; TIMP3	0.928	2.529	0.031
cg16130019	JAZF1	1.029	2.798	0.011
cg16449084	SSH3; ANKRD13D	− 0.865	0.421	0.050
cg16603596	RIMKLB	− 1.142	0.319	0.028
cg18353826	OLFM2	1.069	2.912	0.004
cg19856252	KY	1.151	3.161	0.007
cg22897522	MYH10	− 1.067	0.344	0.006
cg23123250	SPNS2	0.790	2.202	0.031
cg23372684	COL23A1	− 0.975	0.377	0.030
cg23894948	SLC7A4	1.625	5.080	0.000
cg24647724	DNAH9	− 1.634	0.195	0.004
cg25927375	KIRREL3	0.916	2.500	0.005
cg26057780	BDNF	1.528	4.611	0.006

Table containing CpGs whose methylation was used to compose the risk score of metastasis signature plus the co-variable age, significant from the Cox model of metastasis signature

ISSN: 1868-7083