Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival

Table 1 Significant covariables in malignancy signature Cox model

Name	UCSC_RefGene_Name	coef	HR	p.adj
age_at_diagnosis	NA	0.063	1.065	0.000
breslow_thickness_at_diagnosis	NA	0.640	1.896	0.003
cg00033516	FLJ13197; KLF3	1.703	5.490	0.000
cg00144186	FJX1	− 0.775	0.461	0.043
cg00478851	PPFIBP2	1.274	3.575	0.000
cg00489485	WFDC1	0.723	2.061	0.020
cg01607369	PPFIBP2	− 1.217	0.296	0.001
cg03600687	BOK	− 0.910	0.402	0.049
cg04086443	PHGDH	0.717	2.048	0.048
cg05358729	RAB11FIP4	1.377	3.962	0.013
cg06973225	SDC3	− 0.928	0.395	0.049
cg07590102	CDKL5	− 1.767	0.171	0.000
cg08034797	SEPT9	0.602	1.826	0.043
cg08892078	KLHDC8A	− 1.379	0.252	0.001
cg08963581	ZFHX3	0.517	1.677	0.043
cg09070371	HS3ST6	0.759	2.136	0.043
cg10238675	CUX2	0.721	2.056	0.004
cg10581650	MIR1287; PYROXD2	0.993	2.699	0.005
cg12368542	TRIM13; DLEU2	− 1.342	0.261	0.013
cg13206063	MICAL1	− 2.023	0.132	0.000
cg13601997	LMX1B	− 1.280	0.278	0.013
cg13786722	FMN1	1.166	3.210	0.007
cg13935009	CDK18	− 0.936	0.392	0.003
cg16353361	APLN	1.087	2.965	0.003
cg17498321	NOTCH3	− 0.900	0.406	0.015
cg18189288	SPATS2L	0.383	1.467	0.048
cg18329187	CKB	1.387	4.001	0.001
cg19802865	FOXA1	0.686	1.986	0.007
cg21079003	RGMA	1.164	3.203	0.003
cg21642988	DNAJA4	− 0.868	0.420	0.007
cg23109191	GAB2	0.633	1.883	0.007
cg25244036	MAPK4	− 1.475	0.229	0.013
cg25318211	MICAL1	1.154	3.171	0.001
cg26604214	RAP1GAP2	− 0.840	0.432	0.020
cg27417997	SHROOM3	− 0.831	0.436	0.013
gender	NA	− 1.389	0.249	0.021

Table containing CpGs whose methylation was used to compose the risk score of malignancy signature plus the co-variables age, gender, and Breslow depth, all significant from the Cox model of malignancy signature

ISSN: 1868-7083