Fig. 7

Genes from the malignancy signature presenting CpGs’ methylation status with significant prognostic value. Pyrodx2 and Ptgfrn are shown for gene expression (A) and CpG methylation (B) in melan-a, 4C, 4C11− and 4C11+ cell lines. C. Kaplan–Meier plots show the result of overall survival analysis conducted in patients from the TCGA-SKCM cohort, with samples split by CpG methylation status for CpGs of the respective genes. Gene expression is shown as raw fragment counts, with the bar representing standard error. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001 for ANOVA statistical test. CpG methylation sites for the promoter region of the genes are shown as methylated (black circle) for ≥ 70% methylation and white circles for < 70% methylation