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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer

Fig. 6

Construction of the histone modification score. A Differential gene expression analysis showing up (red)- and downregulated genes (blue) in all four histone modification clusters (middle). A gene ontology analysis depicted the enriched pathways of the genes downregulated (left) and upregulated (right) in patients in the HMC4 cluster. Circle size represents the number of genes enriched in this pathway. Circle color depth indicates p value. B Heatmap shows the gene expression patterns of histone modification clusters after dimension reduction using the Boruta algorithm. Red values represent high expression, and blue values represent low expression. Cohort details and histone modification clusters are used as patient annotations. C Principal component analysis of differentially expressed genes to distinguish HMC4 from other histone modifier expression patterns. FC, fold change

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Clinical Epigenetics

ISSN: 1868-7083

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