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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer

Fig. 5

Tumor microenvironment characteristics of distinct histone modifier expression patterns. A and B Heatmaps show immune cell infiltration in the four studied histone modifier expression patterns in the meta-GEO (A) and TCGA-COAD (B) cohorts. Red values represent highly infiltrated cells, and blue values represent minimally infiltrated cells. Histone modifier expression patterns are used as sample annotations. C and D Boxplot of immune cell infiltration in the four studied histone modifier expression patterns in the meta-GEO (C) and TCGA-COAD (D) cohorts. Boxes represent 25–75% of values, lines in boxes represent median values, whiskers represent 1.5 interquartile ranges, and black dots represent outliers. Red terms indicate the highest level of infiltration in patients in the HMC4 cluster. E and F Boxplot of T cell exhaustion level (E) and tertiary lymphoid structure signatures (F) in the four studied histone modifier expression patterns in the meta-GEO (left) and TCGA-COAD (right) cohorts. Boxes represent 25–75% of values, lines in boxes represent median values, whiskers represent 1.5 interquartile ranges, and black dots represent outliers. GJ Boxplot of intratumoral heterogeneity levels (G), tumor purity (H), tumor mutation burden (I), and neoantigen (J) in the four studied histone modifier expression patterns in the TCGA-COAD cohort. Boxes represent 25–75% of values, lines in boxes represent median values, whiskers represent 1.5 interquartile ranges, and black dots represent outliers. *p < 0.05, **p < 0.01, ***p < 0.001; ns, not significant; TEX, T cell exhaustion; TLS, tertiary lymphoid structure; ITH, intratumoral heterogeneity; TMB, tumor mutation burden; single-nucleotide variant; and NEO, neoantigen

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