DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring

Table 3 Negative enriched pathways of GSEA result for placenta transcriptome (top20)

Pathway	Size	NES	P value	FDR
Type I diabetes mellitus	40	− 0.78	< 0.001	< 0.001
Allograft rejection	34	− 0.76	< 0.001	< 0.001
Ribosome	135	− 0.74	< 0.001	< 0.001
Graft-versus-host disease	36	− 0.74	< 0.001	< 0.001
Intestinal immune network for IGA production	44	− 0.72	< 0.001	< 0.001
Autoimmune thyroid disease	41	− 0.70	< 0.001	1.14e-5
Staphylococcus aureus infection	87	− 0.69	< 0.001	9.77e-5
Asthma	28	− 0.69	< 0.001	8.55e-5
Leishmaniasis	74	− 0.66	< 0.001	4.64e-4
Primary bile acid biosynthesis	17	− 0.65	2.63e-3	6.96e-5
Systemic lupus erythematosus	127	− 0.64	< 0.001	1.00e-3
Inflammatory bowel disease	60	− 0.63	< 0.001	1.09e-3
Rheumatoid arthritis	87	− 0.63	< 0.001	1.01e-3
Thiamine metabolism	15	− 0.6	2.67e-3	1.38e-3
Coronavirus disease	220	− 0.62	< 0.001	1.84e-3
Viral myocarditis	57	− 0.61	< 0.001	1.81e-3
Complement and coagulation cascades	83	− 0.60	< 0.001	2.15e-3
Antigen processing and presentation	69	− 0.60	< 0.001	2.11e-3
Pertussis	76	− 0.59	< 0.001	2.99e-3
One carbon pool by folate	20	− 0.58	2.55e-3	3.65e-3

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