DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring

Table 2 Positive enriched pathways of GSEA result for placenta transcriptome (top20)

Pathway	Size	NES	P value	FDR
Cortisol synthesis and secretion	64	0.50	< 0.001	0.16
Adherens junction	71	0.49	< 0.001	0.097
Notch signaling pathway	59	0.48	< 0.001	0.083
Autophagy	32	0.47	< 0.001	0.085
Growth hormone synthesis, secretion and action	118	0.46	< 0.001	0.087
ERBB signaling pathway	85	0.46	< 0.001	0.075
Snare interactions in vesicular transport	33	0.45	5.52e-3	0.075
Lysine degradation	63	0.43	< 0.001	0.10
Ovarian steroidogenesis	50	0.43	< 0.001	0.093
Insulin secretion	84	0.43	< 0.001	0.089
Alpha-linolenic acid metabolism	24	0.42	0.0175	0.086
GNRH signaling pathway	92	0.41	< 0.001	0.10
Prolactin signaling pathway	69	0.41	< 0.001	0.094
Inositol phosphate metabolism	73	0.41	< 0.001	0.091
Chronic myeloid leukemia	76	0.41	< 0.001	0.087
Aldosterone synthesis and secretion	97	0.41	< 0.001	0.082
Phosphatidylinositol signaling system	96	0.40	< 0.001	0.092
Hedgehog signaling pathway	56	0.40	< 0.001	0.087
Endometrial cancer	58	0.40	< 0.001	0.089
Acute myeloid leukemia	67	0.40	< 0.001	0.086

ISSN: 1868-7083