Fig. 4

Classification of late-stage ovarian cancer using DMR from early-stage OC and healthy group. (A) ROC curve of early-stage OC/healthy DMRs in late-stage OC/healthy classification. (B) ROC curve of early-stage OC/healthy DMRs in late-stage OC/Benign classification. (C) Heatmap of the top 300 DMRs between early-stage OC and healthy group. (D) The top 300 DMRs between early-stage OC and the healthy group were used to generate principal component (PC) plots for four cohorts. (E) Relative methylation alteration of the top 300 DMRs identified in early-stage OC/healthy samples was calculated in all sample groups. Hypermethylation was present in the red line, and hypomethylation in blue