| BMI (N = 191) | SF (N = 169) |
---|
Effect (a*b) | SE | LLCI | ULCI | Effect (a*b) | SE | LLCI | ULCI |
---|
Model 1 |
cg04351668 (MARCH9) | 0.056 | 0.053 | − 0.012 | 0.187 | 0.408 | 0.271 | 0.019 | 1.064 |
cg18310007 (EME1) | 0.021 | 0.055 | − 0.071 | 0.151 | 0.446 | 0.298 | − 0.002 | 1.114 |
cg12232388 | 0.075 | 0.048 | 0.004 | 0.189 | 0.704 | 0.264 | 0.245 | 1.262 |
cg12225226 | − 0.141 | 0.057 | − 0.267 | − 0.045 | − 0.140 | 0.181 | − 0.578 | 0.140 |
Model 2 |
cg04351668 (MARCH9) | 0.048 | 0.050 | − 0.017 | 0.178 | 0.368 | 0.282 | 0.004 | 1.060 |
cg18310007 (EME1) | 0.021 | 0.050 | − 0.067 | 0.134 | 0.328 | 0.251 | − 0.071 | 0.899 |
cg12232388 | 0.089 | 0.054 | 0.011 | 0.220 | 0.841 | 0.320 | 0.289 | 1.528 |
cg12225226 | − 0.145 | 0.058 | − 0.277 | − 0.052 | − 0.118 | 0.198 | − 0.612 | 0.185 |
- BMI body mass index; DMPs differential methylated probes; LLCI lower limit confidence interval; SF subcutaneous fat; SE standard error; ULCI upper limit confidence interval; SSBC
- aDMPs were related with maternal sleep midpoint during late pregnancy, and were also associated with offspring’s adiposity indicators
- a*b shows the mediating effect of DMPs in the maternal sleep midpoint–BMI and maternal sleep midpoint–SF relationships, of which “a” shows the coefficient of the association between maternal sleep midpoint and DMPs, and “b” shows the coefficient of the association between DMPs and offspring adiposity indicators
- Model 1: unadjusted
- Model 2: adjusted for maternal age, education level, pre-pregnancy BMI, gestational weight gain, and offspring’s sex
- The bold values indicate statistical significance of p < 0.05