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Table 5 The mediating effect of the selected DMPsa between maternal sleep midpoint during late pregnancy and offspring adiposity indicators at 2 years old in the SSBC sample

From: The mediating effect of DNA methylation in the association between maternal sleep during pregnancy and offspring adiposity status: a prospective cohort study

 

BMI (N = 191)

SF (N = 169)

Effect (a*b)

SE

LLCI

ULCI

Effect (a*b)

SE

LLCI

ULCI

Model 1

cg04351668 (MARCH9)

0.056

0.053

 − 0.012

0.187

0.408

0.271

0.019

1.064

cg18310007 (EME1)

0.021

0.055

 − 0.071

0.151

0.446

0.298

 − 0.002

1.114

cg12232388

0.075

0.048

0.004

0.189

0.704

0.264

0.245

1.262

cg12225226

 − 0.141

0.057

 − 0.267

 − 0.045

 − 0.140

0.181

 − 0.578

0.140

Model 2

cg04351668 (MARCH9)

0.048

0.050

 − 0.017

0.178

0.368

0.282

0.004

1.060

cg18310007 (EME1)

0.021

0.050

 − 0.067

0.134

0.328

0.251

 − 0.071

0.899

cg12232388

0.089

0.054

0.011

0.220

0.841

0.320

0.289

1.528

cg12225226

 − 0.145

0.058

 − 0.277

 − 0.052

 − 0.118

0.198

 − 0.612

0.185

  1. BMI body mass index; DMPs differential methylated probes; LLCI lower limit confidence interval; SF subcutaneous fat; SE standard error; ULCI upper limit confidence interval; SSBC
  2. aDMPs were related with maternal sleep midpoint during late pregnancy, and were also associated with offspring’s adiposity indicators
  3. a*b shows the mediating effect of DMPs in the maternal sleep midpoint–BMI and maternal sleep midpoint–SF relationships, of which “a” shows the coefficient of the association between maternal sleep midpoint and DMPs, and “b” shows the coefficient of the association between DMPs and offspring adiposity indicators
  4. Model 1: unadjusted
  5. Model 2: adjusted for maternal age, education level, pre-pregnancy BMI, gestational weight gain, and offspring’s sex
  6. The bold values indicate statistical significance of p < 0.05