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Table 2 Top gene ontology terms for biological process in brain-enriched group

From: Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms

GOTERM_BP_ALLa

Count

p valueb

Bonferronic

FDR

GO:0099536 synaptic signalling

85

2.58E−16

1.42E−12

4.04E−13

GO:0098916 anterograde trans-synaptic signalling

85

2.58E−16

1.42E−12

4.04E−13

GO:0099537 trans-synaptic signalling

85

2.58E−16

1.42E− 2

4.04E−13

GO:0007268 chemical synaptic transmission

85

2.58E−16

1.42E−12

4.04E−13

GO:0055085 transmembrane transport

131

1.63E−12

1.04E−08

2.04E−09

GO:0007399 nervous system development

187

4.01E−12

2.56E−08

4.18E−09

GO:0048666 neuron development

100

9.98E−11

6.37E−07

8.92E−08

GO:0044708 single-organism behaviour

55

1.18E−10

7.55E−07

9.24E−08

GO:0030182 neuron differentiation

118

1.62E−10

1.03E−06

1.02E−07

GO:0006811 Ion transport

134

1.64E−10

1.05E−06

1.02E−07

GO:0048699 generation of neurons

125

6.82E−10

4.36E−06

3.85E−07

GO:0022008 neurogenesis

131

7.38E−10

4.72E−06

3.85E−07

GO:0034220 Ion transmembrane transport

96

1.96E−09

1.25E−05

9.41E−07

GO:0006836 neurotransmitter transport

33

1.25E−08

7.97E−05

5.29E−06

GO:0031175 neuron projection development

83

1.27E−08

8.10E−05

5.29E−06

GO:0030001 metal ion transport

81

4.83E−08

3.09E−04

1.78E−05

GO:0007610 Behaviour

62

4.84E−08

3.09E−04

1.78E−05

GO:0050804 modulation of synaptic transmission

39

8.38E−08

5.35E−04

2.91E−05

GO:0007267 cell–cell signalling

127

1.43E−07

9.12E−04

4.65E−05

GO:0044707 single-multicellular organism process

387

1.50E−07

9.59E−04

4.65E−05

GO:0098660 inorganic ion transmembrane transport

73

1.56E−07

9.96E−04

4.65E−05

GO:0007611 Learning or memory

33

1.79E07

0.001142057

4.93E05

GO:0042391 regulation of membrane potential

45

1.81E−07

0.001157197

4.93E−05

GO:0030030 cell projection organization

112

2.38E−07

0.00151699

6.20E−05

GO:0007275 multicellular organism development

326

2.77E−07

0.001767572

6.93E−05

GO:0006812 cation transport

89

4.60E−07

0.002937168

1.11E−04

GO:0050890 cognition

35

5.05E−07

0.003220477

1.17E−04

GO:0048812 neuron projection morphogenesis

58

5.53E−07

0.003527699

1.24E−04

  1. aGOTERM_BP_ALL, DAVID gene ontology database; bp value, uncorrected p value; cBonferroni, corrected p value