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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms

Fig. 1

Folic acid methylation changes are particularly enriched at brain-specific genes. A Overview of FA role in DNA methylation-driven benefits for child. Schematic of the EpiFASSTT study and already published results and summary of the results found in this study (grey). Folic acid affects nutritional outcomes for mother and child in the form of maintaining folate levels (green). Psychological analysis of the children supplemented with FA shows clear cognitive benefits (brown arrow). Methylation analysis of the CB samples associates methylation changes with brain-related gene groups (orange). B Number of hyper- (blue) and hypomethylated (red) regions (sites, promoters, and genes) in the top 3000 best-ranking promoters and gene bodies in response to response to FA supplementation in later pregnancy. C Enrichment for tissue-type expression using DAVID and Unigene for the top 3000 best-ranking promoters (i) and gene bodies (ii). Term, Unigene terms; Count; number of genes from the input set in this category; %, per cent of total input; Genes, names of genes from input set falling into this category (first 3 only shown); Fold Enrich, fold enrichment; Benjamini, p value corrected for multiple testing by Benjamini–Hochberg method; FDR false discovery rate score, where 0.05 = 5% of hits being false positive. A significant percentage of promoters and genes changing methylation are expressed in the brain and during early development

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