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Table 3 Look-up of three CpGs identified in cord blood in meta-analysis of epigenome-wide association study results of maternal early-pregnancy serum ferritin concentrations and DNA methylation in older children

From: Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis

CpG

Chr

Position

Gene

Effect

SE

p value

I2

a. Early childhood

cg02806645

3

138,725,153

PRR23A

− 1.9 × 10–4

5.8 × 10–5

7.3 × 10–4

0

cg06322988

3

138,725,189

PRR23A

− 9.7 × 10–5

3.0 × 10–5

1.4 × 10–3

0

cg04468817

16

2,903,392

PRSS22

− 8.4 × 10–5

4.1 × 10–5

3.8 × 10–2

0

b. Late childhood

cg02806645

3

138,725,153

PRR23A

− 2.8 × 10–4

6.3 × 10–5

9.7 × 10–6

0

cg06322988

3

138,725,189

PRR23A

− 5.7 × 10–5

2.8 × 10–5

4.2 × 10–2

77

cg04468817

16

2,903,392

PRSS22

− 1.2 × 10–4

4.0 × 10–5

2.2 × 10–3

0

  1. Chr, Chromosome; SE, standard error; I2, I-square
  2. Effect estimates represent the difference in DNA methylation per 1 µg/L increase in maternal early-pregnancy serum ferritin concentrations. The model was adjusted for gestational age at serum ferritin measurement, maternal age at intake, educational level, pre-pregnancy body mass index, smoking, child sex, child age, cell-type proportions, and batch