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Table 2 Differentially methylated regions associated with maternal early-pregnancy serum ferritin concentrations*

From: Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis

DMR

CpGs

Effect

SE

p value

Nearest genes

Gene Group

chr 3: 138,725,153–138,725,311

cg02806645

− 2.7 × 10−3

4.4 × 10−4

4.0 × 10−10

PRR23A

TSS200

TSS1500

cg06322988

cg01926813

cg07452777

cg03772909

chr 16: 2,902,921–2,903,392

cg06186790

− 2.2 × 10−3

3.9 × 10−4

1.7 × 10−8

PRSS22

3'UTR

Body

cg16701914

cg06077305

cg04468817

  1. Chr, Chromosome; DMR, differentially methylated region; TSS, transcription start site; UTR, untranslated region; SE, standard error
  2. *DMRs were identified from the results of the meta-analysis of epigenome-wide association study results of maternal early-pregnancy serum ferritin concentrations and DNA methylation in cord blood for individual CpGs, which used results from robust linear regression models that were adjusted for gestational age at serum measurement, maternal age at intake, educational level, pre-pregnancy body mass index, smoking, child sex, cell-type proportions, and batch (model 3)
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Clinical Epigenetics

ISSN: 1868-7083

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