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Table 3 Top hits of DMR-analysis of wLE in PD discovery (PDI) and replication sample (PDII)

From: Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder

CpGs included in DMR

Position (hg19)

beta_PDI

p_PDI

beta_PDII

beta_PDII

p_DMR

p_DMR_corrected

cg01987516, cg07044859, cg17888390, cg23904955

chr10: 10,1282,726–101,282,884

1.4077

1.14 × 10−02

1.0837

4.91 × 10−03

2.11 × 10−11

5.60 × 10−08

cg04756515, cg14395744, cg18709881, cg21894287

chr18: 72,837,531–72,837,701

 − 1.008

5.49 × 10−02

 − 0.7770

1.18 × 10−02

2.03 × 10−08

5.06 × 10−05

  1. beta_PDI: effect-size estimate in PDI when taking the mean methylation M-values across all CpGs included in the DMR
  2. p_PDI: nominal p-value in PDI when taking the mean methylation M-values across all CpGs included in the DMR
  3. beta_PDII: effect-size estimate in PDII when taking the mean methylation M-values across all CpGs included in the DMR
  4. p_PDII: nominal p-value in PDII when taking the mean methylation M-values across all CpGs included in the DMR
  5. p_DMR: nominal p-value from DMR-analysis in comb-p on the meta-analysis of PDI and PDII
  6. p_DMR_corrected: p-value from DMR-analysis in comb-p on the meta-analysis of PDI and PDII corrected for multiple testing across all tested regions
  7. The DMR analysis was performed in comb-p. The effect sizes in PDI and PDII using the mean M-values are just displayed for illustration. Comb-p uses the meta-analysis p-values of the single CpGs directly