Table 3 Predicted functions and pathways of genes related with bronchopulmonary dysplasia (BPD) epigenome
Functions and pathways | p-adj* | Selected related genes |
|---|---|---|
Development and lung alveolarization | ||
 Retinoic acid/retinoid X receptor/vitamin D receptor signaling | 1.70E−02 | ARID5A NCOA1 NCOR2 NR0B2 RARRES1 RARRES2 VDR |
 Androgen receptor signaling | 8.30E−03 | BRCA1 CDC42 DSTN FHL2 FOXP1 HSD17B3 NCOA1 NCOR2 NR0B2 PTEN RB1 |
 Lung surfactant metabolism, alveolar epithelial development, glycosaminoglycan metabolism | 2.90E−02 | AGER AHSA1 ARRB1 CAVIN2 CHST14CTSH FNDC3B FOXP1 HS6ST1 MIR449A MIR326 NCOR2 RB1 RBPJ SPOCK2 |
 In utero/embryo growing | 2.10E−02 | AGER AGO2 AKAP13 ARRB1 CDH5 CTNND1 EDN1 NCOA1 NCOR2 NF1 NKX3-2 PBX2 PDPK1 PTEN RARRES2 RB1 VDR |
Hematological system development and vascular disorders | ||
 Platelet activation and coagulation | 9.91E−03 | AGER AMOTL1 ARRB1 CAVIN2 CDC42 CCL17 DGKA EDN1 GNG2 H3C2 ITGA2B LCK PDK1 PDPK1 PTEN SLC39A5 THBS1 |
 Angiogenesis and vascular permeability   IL-8- and CXCR2-mediated signaling,   VEGF/VEGFR2 pathway | 1.44E−02 | ANGPT2 ARRB1 CAVIN2 CCN1 CDH5 CDC42 CTNND1 DOCK2 EDN1 EEF2K EPS15 GNG2 ITGA2B LCK PDK1 PDPK1 PLCB3 SLC39A5 SYNPO2 THBS1 |
 Hematopoiesis   Leukopoiesis, CXCR4-mediated signaling,   PIP3 signaling in B lymphocytes | 8.30E−03 | AGER BAD BRCA1 AREB1 CCL17 CCN1 CDC42 CXCL11 CYTH3 DAPP1 FLOT2 FLT3LG GNG2 IKZF2 LCK NF1NR0B2 PDPK1 PLCB3 PTEN UBQLN1 |
 Enucleation of erythroid precursor cells | 1.44E−02 | HIPK2 RB1 MAEA RHAG |
 Megakaryocyte differentiation   Aryl hydrocarbon receptor signaling,   RUNX1 regulation | 2.09E−02 | AGO2 ALDH16A1 ALDH3A1 CDC42 DOCK2 GNG2 H2AC4 H3C2 ITGA2B KIF1B LCK NCOR2 NEDD8 NR0B2 PSMB8 RB1 THBS1 |
Cell proliferation and extracellular matrix | ||
 Smooth muscle proliferation, muscle morphology and size, skeletal system development | 1.40E−02 | AGER AGTRAP AKAP13 ANGPT2 CHRM5 CLASP1 EDN1 FHL2 FOXP1 KEL LDB3 MYOZ2 NCOA1 NF1 PDPK1 PTEN RARRES2 RASGRF1 RB-SKI RB1 RBPJ TERC THBS1 TNFSF9 TRPM2 VDR ZBTB16 |
 Epithelial-mesenchymal transition, extracellular matrix organization | 3.46E−02 | BANP BRCA1 BTBD7 CCN1 CDC42 CLASP1 COL21A1 FNDC3B ITGA2B LAMB3 MFAP3L MIR193B NCOA1 PDPK1 PHLDB2 PTEN RB1 RBPJ SLC25A33 THBS1 UBQLN1 VEPH1 |
Mitochondrial energy metabolism Response to decreased O2 level, glucose deprivation | 1.13−E02 | AGER AGTRAP ALDH3A1 ANGPT2 EDN1 EEF2K GHSR HIPK2 MDH1 MRPL14 NF1 PDK1 PKLR PKM PSMB8 PTEN RBPJ RHAG SLC25A26 SLC25A33 TERC THBS1 TOMM7 UBQLN1 |
Retinal disorder, inner ear development | 4.66−E02 | CAVIN2 CCN1 FJX1 GBP3 GJB6 HIPK2 LCK PTEN RB1 RBPJ TMEM63B |
Immune and inflammatory responses | 1.27−E02 | AGER AGTRAP ANGPT2 ARRB1 CCN1 CCNT1 CDC42 CDH5 CXCL11 CYP7B1 DOCK2 EDN1 FLT3LG GPR18 KAT8 LCK MYO1G PDK1 PLCB3 PNKP PSMB8 PTEN RARRES2 RB1 TERC TNFSF9 TOP1 TRPM2 UBQLN1 VDR |
Production of reactive oxygen species | 1.81−E02 | AGER AGTRAP ANGPT2 BRCA1 CCN1 CDC42 CDH5 DOCK2 EDN1 LCK PDK1 PLCB3 PNKP PSMB8 PTEN RARRES2 RB1 RRBPJ SLC25A33 TOP1 TRPM2 UBQLN1 VDR |