Fig. 3

Epigenome-wide association study (EWAS) for bronchopulmonary dysplasia (BPD) risk in preterm infants. A Manhattan plot of robust linear regression model-based cord blood CpGs associated with BPD risk in Argentina preterm infant cohort (n = 107). Thirty-eight CpGs were significant following Bonferroni cutoff (p < 1.04E−07, red line) and 275 CpGs were significant at false discovery rate < 0.01 (blue line). Representative gene names annotated to the differentially methylated CpGs are labeled and depicted by arrows. AGER advanced glycosylation end-product-specific receptor, ALDH3A1 aldehyde dehydrogenase 3 family member A1, CAVIN2 Caveolae-associated protein 2, CTSH cathepsin H, DSTN destrin, EEF2K eukaryotic elongation factor 2 kinase, GBP3 guanylate-binding protein 3, GJB6 gap junction protein beta 6, MAEA macrophage erythroblast attacher, MYO1G myosin IG, NCOR2 nuclear receptor corepressor 2, RARRES1 retinoic acid receptor responder 1, PARP6 protein mono-ADP-ribosyltransferase, PKM pyruvate kinase, RBPJ recombination signal-binding protein for immunoglobulin kappa J region, SPOCK2 SPARC (osteonectin), Cwcv and Kazal-like domains proteoglycan 2, ST6GALNAC3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, TOMM7 translocase of outer mitochondrial membrane 7, VDR vitamin D (1,25- dihydroxy vitamin D3) receptor