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Table 1 Top significant CpG probe in the epigenome-wide association study on the epi-cblC phenotype

From: Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B12

CpG probe

Chr

Position*

CpG island

Locus

t-test, P-value

t-test, Bonf. P-value

β-value (Cases)

β-value (Controls)

Δβ-value

cg12630522

1

45956424

CpG:51

TESK2 (promoter)

3.86E-223

1.74E-217

0.55

0.01

0.54

cg19250177

1

45956646

CpG:51

TESK2 (promoter)

7.56E-204

3.42E-198

0.46

0.01

0.45

cg25827112

1

45956773

CpG:51

TESK2 (promoter)

4.96E-192

2.25E-186

0.46

0.06

0.41

cg27633763

1

45956828

CpG:51

TESK2 (promoter)

1.22E-94

5.53E-89

0.49

0.03

0.47

cg19551082

1

45956882

CpG:51

TESK2 (promoter)

3.62E-148

1.64E-142

0.32

0.06

0.27

cg00103132

1

45956932

Upstream 5’ end CpG:51

Upstream 5’ end TESK2

4.42E-212

2.00E-206

0.42

0.04

0.38

cg00609097

1

45956974

Upstream 5’ end CpG:51

Upstream 5’ end TESK2

6.61E-195

2.99E-189

0.48

0.05

0.43

cg24296786

1

45957014

Upstream 5’ end CpG:51

Upstream 5’ end TESK2

2.75E-199

1.24E-193

0.53

0.05

0.48

cg04132845

1

45957038

Upstream 5’ end CpG:51

Upstream 5’ end TESK2

1.96E-218

8.85E-213

0.46

0.06

0.41

cg15605315

1

45957053

Upstream 5’ end CpG:51

Upstream 5’ end TESK2

3.07E-196

1.39E-190

0.50

0.03

0.46

cg05765466

1

45957060

Upstream 5’ end CpG:51

Upstream 5’ end TESK2

8.34E-203

3.77E-197

0.46

0.08

0.38

cg13848568

1

45965625

CpG:33

CCDC163P–MMACHC (bidirectional promoter)

1.87E-138

8.44E-133

0.39

0.04

0.35

cg00081251

1

45965679

CpG:33

CCDC163P–MMACHC (bidirectional promoter)

2.89E-182

1.31E-176

0.52

0.07

0.45

cg09323228

1

45965727

CpG:33

CCDC163P–MMACHC (bidirectional promoter)

1.18E-171

5.33E-166

0.49

0.05

0.44

cg27393325

1

45965846

CpG:33

CCDC163P–MMACHC (bidirectional promoter)

2.16E-195

9.79E-190

0.52

0.02

0.50

cg22536808

1

45965870

CpG:33

CCDC163P–MMACHC (bidirectional promoter)

7.73E-167

3.50E-161

0.42

0.00

0.42

cg14836864

1

45965990

CpG:33

CCDC163P–MMACHC (bidirectional promoter)

2.33E-167

1.05E-161

0.43

0.03

0.40

cg03108114

1

45966048

CpG:33

CCDC163P–MMACHC (bidirectional promoter)

1.51E-208

6.82E-203

0.54

0.02

0.51

  1. Chr chromosome; Bonf. Bonferroni; Δβ-value difference between case and control β values
  2. *Genomic positions are reported according to GRCh37
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Clinical Epigenetics

ISSN: 1868-7083

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