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Fig. 3 | Clinical Epigenetics

Fig. 3

From: DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy

Fig. 3

TIGIT protein expression in tonsillar and melanoma tissue. Representative immunohistochemical staining patterns in a tonsil (a) and various melanomas (b–f). a In tonsillar tissue (positive control), lymphatic germinal centers stain strongly positive in proximity to the mantle zone. b Melanoma with TIGIT+ TILs and TIGIT− tumor cells (H-score = 0). c, d Melanomas with dense immune cell infiltrate; both tumor and immune cells weakly/moderately positive for TIGIT expression (c: H-score = 190, d: H-score = 145). e Melanoma with TIGIT− TILs and TIGIT− tumor cells (H-score = 0). f Melanoma with strong TIGIT expression in the majority of tumor cells (H-score = 230). a-f Original magnification 200×, scale bar indicates 100 µm in the main photograph; scale bar indicates 25 µm in the magnified areas

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Clinical Epigenetics

ISSN: 1868-7083

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