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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy

Fig. 2

Correlations between TIGIT DNA methylation, mRNA expression, and infiltrates. Scatter plots of correlations between TIGIT mRNA and CpG5 methylation (a), TIGIT CpG5 methylation and lymphocyte score (according to TCGA [39]; b), TIGIT CpG5 methylation and leukocyte fraction (according to Saltz et al. [41]; c), TIGIT CpG5 methylation and lymphocytes (according to Thorsson et al. [40]; d), TIGIT mRNA expression and lymphocyte score (e), TIGIT mRNA expression and leukocyte fraction (f), and TIGIT mRNA expression and lymphocytes (g). Expression levels of 0 n.c. were set to 0.1 n.c. in order to allow for a logarithmic illustration. Shown are Spearman’s ρ rank correlation coefficients and P values

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