Table 3 Distributions of low methylation (LM,āā¤ā20%), intermediate methylation (IM, 20ā80%) and high methylation (HM,āā„ā80%) in genetic elements (NEC vs. non-NEC)
Characteristics | Ileum | LM (%) | IM (%) | HM (%) | Chi-square p value non-NEC v. NEC |
|---|---|---|---|---|---|
All sites | Non-NEC ileum | 575,934 (28.93) | 705,262 (35.43%) | 709,267 (35.63%) | pā<ā2.2āĆā10ā16 |
| Ā | NEC ileum | 573,632 (28.82) | 640,256 (32.17%) | 776,575 (39.01%) | Ā |
Prom No CGI | Non-NEC ileum | 142,630 (45.24) | 120,866 (38.33%) | 51,811 (16.43%) | pā<ā2.2āĆā10ā16 |
| Ā | NEC ileum | 140,603 (44.59) | 112,387 (35.64%) | 62,317 (19.76%) | Ā |
Prom & CGI | Non-NEC ileum | 222,275 (92.27) | 9796 (4.07%) | 8832 (3.67%) | pā=ā0.03942 |
| Ā | NEC ileum | 222,367 (92.31) | 9508 (3.95%) | 9028 (3.75%) | Ā |
Intron/Exon No CGI | Non-NEC ileum | 66,057 (9.42) | 313,258 (44.67) | 322,030 (45.92) | pā<ā2.2āĆā10ā16 |
| Ā | NEC ileum | 65,109 (9.28) | 279,244 (39.82) | 356,992 (50.90) | Ā |
Intergenic CGI | Non-NEC ileum | 37,602 (49.74) | 14,547 (19.24) | 23,451 (31.02) | pā=ā0.02158 |
| Ā | NEC ileum | 37,877 (50.10) | 14,125 (18.68) | 23,598 (31.21) | Ā |
Intron/Exon & CGI | Non-NEC ileum | 194,501 (62.82) | 28,989 (9.36) | 86,141 (27.82) | pā=ā0.0002086 |
| Ā | NEC ileum | 195,213 (63.05) | 28,053 (9.06) | 86,365 (27.89) | Ā |
CGI Shores | Non-NEC ileum | 23,994 (30.41) | 29,250 (37.07) | 25,665 (32.52) | pā<ā2.2āĆā10ā16 |
| Ā | NEC ileum | 24,064 (30.50) | 26,084 (33.06) | 28,761 (36.45) | Ā |
Intergenic | Non-NEC ileum | 26,663 (6.38) | 194,292 (46.46) | 197,234 (47.16) | pā<ā2.2āĆā10ā16 |
| Ā | NEC ileum | 26,253 (6.28) | 176,432 (42.19) | 215,504 (51.53) | Ā |