Selective hypermethylation is evident in small intestine samples from infants with necrotizing enterocolitis

Clinical Epigenetics

Table 1 Proportion of CpG sites in different genomic elements that were hyper- or hypomethylated in NEC versus non-NEC control ileum

Region	Hypermethylated in non-NEC	Hypermethylated in NEC	Neither	Fraction hypermethylated in non-NEC	Fraction hypermethylated in NEC	p value
All Sites	25,616	71,961	1,990,463	0.013	0.036	NA
Prom No CGI	3776	15,571	315,307	0.012	0.049	0
Prom & CGI	585	782	240,903	0.002	0.003	0
Intron/Exon No CGI	10,259	32,288	701,345	0.015	0.046	0
Intergenic CGI	1391	1054	75,600	0.018	0.014	8.81 × 10⁻²⁷⁴
Intron/Exon & CGI	3198	2496	309,631	0.010	0.008	0
CGI Shores	1153	2874	78,909	0.015	0.036	6.79 × 10⁻⁰⁵
Intergenic	5637	17,389	418,189	0.013	0.042	2.21 × 10⁻⁹³

Only CpG sites with differing methylation levels between NEC and non-NEC by > 10% are included

ISSN: 1868-7083