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Table 2 Top 10 differentially hypo- and hypermethylated CpGs associated with CPM efficiency in adults with cLBP

From: Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain

Chr

Position

p-value

q-value

Methylation difference

Genes

Hypomethylated CpGs

    

1

7062216

1.99 × 10–42

1.84 × 10–37

22.97

LOC105376692

1

208071630

1.79 × 10–42

1.84 × 10–37

29.33

LOC105372887

22

20636231

1.97 × 10–32

1.04 × 10–27

20.64

POM121L4P

14

101202752

4.65 × 10–30

1.72 × 10–25

13.84

LINC02285

8

49401429

7.47 × 10–27

1.63 × 10–22

16.29

LOC100507464

6

4892147

1.66 × 10–25

2.87 × 10–21

11.90

CDYL

7

152500728

1.71 × 10–25

2.87 × 10–21

22.73

LOC105375574

20

4873285

7.88 × 10–25

1.27 × 10–20

24.27

RASSF2

19

47358835

1.35 × 10–24

2.08 × 10–20

14.80

DHX34

5

170149514

1.98 × 10–23

2.72 × 10–19

13.26

FOXI1

Hyper methylated CpGs

    

12

121444044

2.41 × 10–45

8.94 × 10–40

− 35.22

MIR7107

5

101611746

7.01 × 10–43

1.30 × 10–37

− 23.10

LOC105379102

4

183768629

1.09 × 10–35

8.09 × 10–31

− 23.97

STOX2

3

88191286

6.66 × 10–33

4.11 × 10–28

− 24.67

C3orf38

14

89052404

1.85 × 10–30

8.56 × 10–26

− 16.27

LOC105370615

11

7519699

3.60 × 10–30

1.48 × 10–25

− 17.93

PPFIBP2

2

129828813

1.25 × 10–29

4.21 × 10–25

− 17.29

LOC107985945

9

30199307

6.57 × 10–28

2.03 × 10–23

− 23.93

LINC01242

22

21680479

2.33 × 10–27

6.65 × 10–23

− 19.36

PPIL2

8

19974465

3.11 × 10–27

7.69 × 10–23

− 16.39

LPL

  1. Differential methylation based on comparison of efficient versus deficient CPM in adults with chronic low back pain
  2. Chr, chromosome; DML, differentially methylated loci;