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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis

Fig. 5

Behavioral and molecular analysis in ISO rats. a ISO rats (n = 8) housed individually for five weeks (from PND 21 to PND 54, ISO) showed an anxious-like phenotype in the open field test, as they spent less time in the center of the arena compared to CTRL animals (n = 8). Moreover, ISO rats showed stereotypic behaviors as they displayed a higher frequency of wall rearing (b) and more head dippings in the hole-board test (c); d–g Oxtr relative gene expression in the AM, PFC, HYP and DStr of ISO and CTRL rats. Scattered plots represent 2 (−DDCt) values calculated by the DDCt method [** p < 0.01]; h–j correlations between Oxtr expression and behavioral outcomes. Data were compared by Spearman's rank correlation coefficient

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Clinical Epigenetics

ISSN: 1868-7083

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