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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis

Fig. 2

Transcriptional regulation of OXTR gene in PBMCs of OCD and control (CTRL) subjects. a Schematic representation of human OXTR gene. Translation start codon (ATG), exons and introns are depicted. Coding regions of exons are shown darker. Sequence of the CpG island under study is also reported. Bold text indicates the 4 CpG sites analyzed; b OXTR mRNA levels in PBMCs from patients diagnosed with OCD and CTRL subjects. Scattered plots represent 2 (−DDCt) values calculated by the DDCt method [****p < 0.001]; c OXTR exon III DNA methylation levels in PBMCs of OCD and CTRL subjects represented as scattered plot for individual CpG sites under study as well as of the average (AVE) of the 4 CpG sites [*p < 0.05]; d correlation between OXTR gene expression and % change of DNA methylation in the overall human population under study. Data were compared by Spearman's rank correlation coefficient

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