Fig. 1

Mutational and transcriptional study of SWI/SNF in LUAD primary tumors (A) Mutation profile of the 20 lung SWI/SNF complex subunits in our LUAD cohort. Y axis represents all the subunits that had at least one genetic alteration in at least one LUAD patient. X axis gathers all LUAD patients with a mutant SWI/SNF complex. On the left, mutation frequencies of these lung SWI/SNF subunits in our LUAD patients. (B) Tile plot of the mRNA expression of the lung SWI/SNF subunits in our LUAD cohort. Blue colors correspond to those genes that showed ≤ -2 × expression in the tumor sample than in the matched normal sample. Orange colors are displayed when a gene was expressed ≥ 2 × in the tumor. White colors correspond to those expression values that did not reach the thresholds that we defined for upregulation or downregulation. Red circles are present when a certain gene was mutated in a specific patient. On the left side, lung SWI/SNF genes are arranged based on downregulation percentage in our LUAD patients. At the bottom of the tile plot, our 70 LUAD patients are arranged based on the number of lung SWI/SNF subunits that were downregulated in their tumors