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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Data mining of bulk and single-cell RNA sequencing introduces OBI1-AS1 as an astrocyte marker with possible role in glioma recurrence and progression

Fig. 2

A t-SNE of 19 brain cell types. Each point is a cell. Red cluster belongs to astrocytes. B–E The expression pattern of astrocyte markers including GFAP (C), S100B (D) and SLC1A3 (E) confirmed that the red cluster in A belonged to the astrocyte. OBI1-AS1 expression was also plotted in t-SNE (B), and the pure red color in this figure indicated that OBI1-AS1 is exclusively expressed in astrocytes. F Violin graph shows that OBI1-AS1 is significantly expressed in astrocytes. Each point is a cell. G ROC curve analysis of GFAP, S100B, SLC1A3, ALDOC, AQP4, ALDH1L1, and OBI1-AS1 showed that OBI1-AS1 had significantly higher specificity and sensitivity compared to other markers for differentiating astrocyte from other cell types

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Clinical Epigenetics

ISSN: 1868-7083

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