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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Trans-acting genetic variants causing multilocus imprinting disturbance (MLID): common mechanisms and consequences

Fig. 2

Relative distribution (Y axis) of LOM at the clinically relevant DMRs in correlation to the maternal effect and ZFP57 genes. (Please note that abbreviated names for the DMRs are listed). a Distribution of LOM in the whole cohort. b Imprinting signature in those families in which biallelic and homozygous maternal variants have been identified. Only individuals for whom methylation data were available were included. y-axis indicates the number of the individuals. PLAGL1, PLAGL1:alt-TSS-DMR; GRB10, GRB10:alt-TSS-DMR; MEST, MEST:alt-TSS-DMR; IC1, H19/IGF2:IG-DMR; IC2, KCNQ1OT1:TSS-DMR; MEG3, MEG3/DLK1:IG-DMR; SNRPN, SNURF:TSS-DMR; PEG3, PEG3:TSS-DMR; GNAS, GNAS DMRs

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Clinical Epigenetics

ISSN: 1868-7083

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