Skip to main content
Fig. 3 | Clinical Epigenetics

Fig. 3

From: Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes

Fig. 3

Effect of bariatric surgery on transcriptional profile, epigenetic landscape and cell functions. a Body weight (BW) and biochemical values distribution across the four studied groups: obese (dark green); lipodystrophy (blue); blood donors (BD) (light red); and post-bariatric surgery patients (light green). Asterisks indicate result of significance from multiple logistic regression models and conditional multiple logistic regression for obese versus post-surgery comparison. Significance is annotated as follows: *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001. b Bar plot shows number of features significantly different when comparing obese individuals before and after bariatric surgery, coloured by cell types. c Volcano plot showing differentially abundant plasma proteins when comparing obese individuals before and after bariatric surgery. Whole blood-specific genes associated with differentially abundant proteins have been annotated. d RNA-Seq expression in the 4 different cell types of highlighted proteins in (c). Asterisks indicate if the gene was differentially expressed in at least one cell type. e Neutrophil ability to attach in the absence of any stimuli after bariatric surgery and it is expressed using the plate reader arbitrary units (RFU). f Adhesion percentage of neutrophils measured in the presence of different pro-inflammatory molecules in obese (dark green) and post-surgery (light green) individuals. Asterisks indicate the result of significance from paired t test. Significance is annotated as follows: *p ≤ 0.05; **p ≤ 0.01

Back to article page