Fig. 3
From: Roles for the methyltransferase SETD8 in DNA damage repair
The functional domains of BRCA1-BARD1 and proposed model for bivalent nucleosome recognition by BRCA1/53BP1. (a) The functional domains of BRCA1 and BARD1. The RING domains of BRCA1 and BARD1 mediate their heterodimerization and is crucial for the E3 ubiquitin ligase activity of the BRCA1-BARD1 complex (b) Proposed model for 53BP1 and BRCA1 recruitment by bivalent nucleosome recognition. Their recognitions of shared H2AK15ub-modified nucleosomes, but distinct methylation states of H4K20, ensure their respective preference for chromatins in a DSB-dependent-specify and a cell cycle-dependent-specify, respectively, which dictates choice of DSB repair pathways