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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Chromatin accessibility and transcriptome integrative analysis revealed AP-1-mediated genes potentially modulate histopathology features in psoriasis

Fig. 1

BETA activating/repressive function prediction of psoriatic lesions. A BETA analysis graphs depicting the effect of differentially open ATAC peaks in psoriatic lesions. Genes were ranked from high to low according to the regulatory potential of the corresponding chromatin peak. Purple lines represent downregulated genes, while red lines represent upregulated genes. B BETA-plus conjoins factor binding and differential gene expression data to analyze sequence motifs in upregulated target genes (UP). Because of their high similarity scores, JUND, NFE2L2, IRF4, and seven other Leucine Zipper family members are categorized into one group. C Motif comparison between UP and NON regions represent potential collaborating factors

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Clinical Epigenetics

ISSN: 1868-7083

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