Characteristics | Tissue sample | Blood sample | ||
---|---|---|---|---|
Breast cancer N = 34 | Control N = 50 | Breast cancer N = 79 | Control N = 91 | |
Age, years | 48.3 ± 12.2 | 46.7 ± 20.8 | 54.6 ± 13.6 | 48.5 ± 17.7 |
Cohort (Komen/Yale) | 0/34 | 45/5 | 0/79 | 44/47 |
Age groups | ||||
< 50 years | 21 | 27 | 32 | 44 |
≥ 50 years | 13 | 23 | 47 | 47 |
Race/ethnicity | ||||
Non-Hispanic White | 23 | 45 | 62 | 79 |
Hispanic White | 3 | 2 | 3 | 4 |
Africa American | 4 | 3 | 7 | 6 |
Others | 4 | 0 | 7 | 2 |
Body mass index | 26.6 ± 4.9 | 26.9 ± 5.3 | 28.2 ± 6.1 | 28.5 ± 6.7 |
Smoking | ||||
Non-smoker | 21 | 31 | 44 | 56 |
Former smoker | 12 | 14 | 30 | 25 |
Current smoker | 1 | 5 | 5 | 10 |
Alcohol consumption | ||||
No | 18 | 3 | 21 | 3 |
Yes | 16 | 47 | 58 | 88 |
Age at first birth | 25.5 ± 5.6 | 25.8 ± 3.4 | 26.0 ± 5.0 | 26.2 ± 4.5 |
Menopause, yes | ||||
No | 24 | 25 | 35 | 37 |
Yes | 10 | 25 | 44 | 54 |
Age at menses onset | 12.3 ± 1.7 | 12.5 ± 1.1 | 12.7 ± 1.7 | 12.4 ± 1.4 |
Number of birth | 1.8 ± 1.4 | 2.2 ± 0.6 | 1.9 ± 1.4 | 2.1 ± 1.0 |
Total pregnancy | 2.3 ± 1.9 | 2.5 ± 1.0 | 2.3 ± 1.9 | 2.6 ± 1.5 |
ER/PR | ||||
+/+ | 23 | − | 49 | − |
± | 1 | − | 2 | − |
−/− | 1 | − | 10 | − |
Unknown | 9 | − | 18 | − |
HER2 | ||||
Positive | 3 | − | 4 | − |
Negative | 24 | − | 58 | − |
Not typed/insufficient tissuee | 7 | − | 10 | − |
Unknown | 0 | − | 7 | − |
BRCA testing | ||||
Positive | 2 | − | 2 | 0 |
Negative | 16 | − | 49 | 33 |
Results unknown | 6 | − | 12 | 0 |
Not tested | 10 | − | 16 | 9 |
Oral contraceptive pill use | ||||
Current and former user | 5 | 3 | 26 | 36 |
Never | 13 | 0 | 23 | 8 |
Unknown | 16 | 47 | 30 | 47 |
Ever hormone replacement therapy | ||||
Yes | 3 | 45 | 12 | 20 |
No | 3` | 35 | 67 | 71 |