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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Atheroprotective mechanism by which folic acid regulates monocyte subsets and function through DNA methylation

Fig. 4

FA reverses ox-LDL- and Hcy-mediated promotion of intermediate monocyte proportions and CCR2 expression. Primary monocytes were induced using 50 μm/L ox-LDL, 50 mg/L Hcy, and 0.5 μm/L FA. A Negative control. B ox-LDL- and C ox-LDL + FA-treated primary monocytes. D Hcy- and E Hcy + FA-treated primary monocytes. F The proportion of intermediate monocytes among induced primary monocytes (%). G The expression level (MFI) of CCR2 on classical monocytes. H The expression level (MFI) of CCR2 on intermediate monocytes. All plotted values are the mean ± SE values of at least three independent experiments. m1, classical monocytes; m2, intermediate monocytes; MFI, median fluorescence intensity; NC, negative control. *p < 0.05, **p < 0.01, ****p < 0.0001

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