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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Atheroprotective mechanism by which folic acid regulates monocyte subsets and function through DNA methylation

Fig. 3

FA reverses the suppressive effects of ox-LDL and Hcy on DNA methylation and ARID5B expression. A The effect of FA on global 5-mC levels in THP-1 cells. B, C The effect of FA on global 5-mC levels in ox-LDL- and Hcy-treated THP-1 cells. D, E The effect of FA on the expression of DNMT1 in ox-LDL- and Hcy-treated THP-1 cells. F, G The effect of FA on the expression of ARID5B in ox-LDL- and Hcy-treated THP-1 cells. H, I The effect of FA on the methylation of cg25953130 in ox-LDL- and Hcy-treated primary monocytes. All plotted values are the mean ± SE values of at least three independent experiments. FA, folic acid; Hcy, homocysteine; ox-LDL, oxidized low-density lipoprotein. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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