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Table 1 Hematological responses following exercise

From: Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy

 

Pre

Post

+ 30′

Chi-square

P

cfDNA (ng/ml)

8.5 (8.2; 9.5)

80 (55.6; 142.7)

19.8 (14.9; 28.9)

20

4.54E−05

Leukocytes (G/L)

6 (5.6; 6.1)

9.5 (8.7; 12)

7.1 (6; 7.5)

15.8

0.000371

Monocytes (G/L)

0.4 (0.4; 0.6)

0.7 (0.6; 0.8)

0.5 (0.4; 0.6)

15.2

0.0005

Granulocytes (G/L)

3.7 (3.1; 4.3)

5.4 (4.4; 8.1)

5.1 (3.5; 5.4)

16.2

0.000304

Lymphocytes (G/L)

1.7 (1.4; 1.9)

3.1 (2.4; 3.7)

1.5 (1.3; 1.5)

18.2

0.000112

Cellular DNA monocytes (%)

18.5 (15.3; 23.9)

5.2 (3.8; 7.6)

12.2 (10.4; 16.7)

14.6

0.000676

Cellular DNA granulocytes (%)

54.1 (50.1; 61.8)

90.2 (79.7; 94.4)

66.9 (64.2; 73.8)

18.2

0.000112

Cellular DNA lymphocytes (%)

20.4 (18; 24.2)

3.5 (0.6; 9.2)

12.9 (7.9; 15.5)

11.4

0.003346

Cellular DNA other cell types (%)

3 (0.2; 6.2)

0 (0; 1)

6.3 (0.7; 9)

2.6

0.272532

Conc. of monocyte cfDNA (ng/ml)

1.7 (1.4; 2.2)

4.9 (3.6; 6.9)

3 (2.3; 4.7)

9.8

0.007447

Conc. of granulocyte cfDNA (ng/ml)

5.3 (4.4; 5.4)

67.6 (46.7; 136.1)

10.8 (9.3; 19.8)

20

4.54E−05

Conc. of lymphocyte cfDNA (ng/ml)

1.9 (1.5; 2.3)

2.1 (0.5; 8)

2.1 (1.9; 3.7)

0.6

0.740818

Conc. cfDNA other cells (ng/ml)

0.3 (0; 0.7)

0 (0; 0.8)

1.2 (0.1; 1.6)

1.4

0.496585

  1. Data are expressed as median (25th, 75th percentiles). The relative concentration of cfDNA from different cell types was calculated by multiplying the cfDNA concentration with the cellular DNA amount (%). Global statistical differences were calculated with nonparametric Friedman rank sum test