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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Novel epigenetic network biomarkers for early detection of esophageal cancer

Fig. 5

Correlation of CCL20 module with EAC status in saliva. a Violin plots displaying the total epithelial fraction (fEPI, y-axis), as estimated using HEpiDISH with our Epithelial-Fibroblast-ImmuneCell DNAm reference, against disease stage (x-axis) in the two saliva cohorts, as indicated. P values derive from a one-tailed Wilcoxon rank sum test, comparing each disease stage to the normal-state. N = normal, NDBE = non-dysplastic Barrett’s Esophagus, HGD = high grade dysplasia, C = Esophageal Adenocarcinoma. b Scatterplot of the estimated total epithelial fraction (fEPI, y-axis) vs the estimated squamous buccal epithelium fraction (x-axis). Pearson correlation coefficient (PCC) and P value are given. Samples have been colored according to disease stage using same coloring scheme as in (a). c As (b), but now displaying the estimated esophageal adenoma carcinoma cell fraction along the x-axis. d Violin plots displaying the FEM EAC score (y-axis) versus disease stage (x-axis), for the CCL20-module in the two saliva cohorts. P values derive from a one-tailed Wilcoxon rank sum test, comparing each disease stage to the normal-state

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