Fig. 4
From: Aberrant epigenetic and transcriptional events associated with breast cancer risk
Age-related transcriptome and DNA methylation changes in healthy breast tissues. A Differentially expressed genes between the first (D1) and second (D2) donation time point in the breast tissues from average (blue bars) and high- (orange bars) risk women. Ratio between D2 and D1 is shown. B Pearson’s correlation test between DNA methylation and transcription of GRIA4 and DNM3 in average- and high-risk breasts at the two time points, D1 and D2, C Number of genomic locations (intron, coding regions, promoter, UTR) of the age-related DNA methylation events. N.A.: not available. D Venn diagram of the DNA methylation changes associated with age comparing our data set (D2/D1) with Horvath’ epigenetic clock (353 CpGs) or Johnson’s age-associated loci (787 CpGs) E Differentially methylated regions between the first (D1) and second (D2) donation time point in the breast tissues from average (blue bars) and high- (orange bars) risk women. Ratio between D2 and D1 is shown. *p < 0.05; **p < 0.001