Fig. 2
From: Aberrant epigenetic and transcriptional events associated with breast cancer risk
Methylome profiling of breast tissues from women at either high- or average risk of breast cancer. A Chromosomal distribution of the DNA methylation aberrations observed in high-risk versus average-risk group. B Heatmap of the 20 highest differentially methylated regions in high-risk breasts as compared with average-risk breasts at FDR < 0.05. The overlapping gene name is indicated on the left. C Genomic localization (intron, coding, promoter or UTR) of the DNA methylation aberrations including regions either hypo- or hyper-methylated in high-risk versus average-risk breasts. Data are shown as percentage of each genomic localizaton versus the total number of sites. D Pathway analysis of the genes affected by DNA methylation aberrations (FDR < 0.05) in high-risk breasts as compared with breast from women at average risk for breast cancer. E One of the molecular networks including the genes affected by DNA hypermethylation