Fig. 5
From: Gender-affirming hormone therapy induces specific DNA methylation changes in blood
Detailed DNA methylation map of the VMP1 gene. A Map of the VMP1 gene in hg19, showing EPIC probe locations. B Mean DNA methylation level at VMP1 for transgender women at baseline, 6 months GAHT, and 12 months GAHT. Error bars are 95% confidence intervals. Nine DMPs show the same direction of DNA methylation change within the DMR. C Line plot showing individual donor changes in DNA methylation for the top 3 probes within the VMP1 DMR. D Bar plot showing difference in DNA methylation between people assigned female at birth and people assigned male at birth at the top 2 VMP1 probes at birth and in adults. E Boxplot of cg12054453 in blood at birth (Guthrie cards) and in adults (23-35yo), showing that sex-specific DNA methylation at this probe become significant during the lifetime. *p value < 0.01