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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Gender-affirming hormone therapy induces specific DNA methylation changes in blood

Fig. 4

Detailed DNA methylation map of the PPR4 gene. A Map of the PRR4 gene in hg19, showing EPIC probe locations. B Mean DNA methylation level at PRR4 for transgender men at baseline, transgender men at 12 months GAHT, and control individuals assigned male at birth. Error bars are 95% confidence intervals. Four DMPs within the DMR are losing DNA methylation in response to masculinizing GAHT, in the direction towards DNA methylation level typical of people assigned male at birth. C Line plot showing individual donor changes in DNA methylation for top probe within the PRR4 DMR—cg23256579. D Boxplot of cg23256579 in blood at birth (Guthrie cards) and in adults (age 23–35), showing that sex-specific DNA methylation at this probe arises during the lifetime

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