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Table 2 Cox proportional hazards 10-year recurrence-free survival models

From: Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes

 

n (%) event#

n (%) no-events#

Event occurrence months

Multivariable$ model

Mean

Median

HR (95% CI)

P value

Age

373 (61.9)

230 (38.1)

65.6

62.0

1.01 (1.00–1.03)

0.024

Tumor grade

      

1 + 2

263 (58.2)

189 (41.8)

69.9

79.0

Referent group

 

3 + 4

110 (72.8)

41 (27.2)

52.8

26.7

1.48 (1.17–1.87)

1.0E−3

Smoking status

      

Non-smoker

47 (45.6)

56 (54.4)

82.3

120.0

Referent group

 

Ever-smoker

326 (65.2)

174 (34.8)

62.2

51.9

1.65 (1.22–2.25)

1.0E−3

mdNLR*

373 (61.9)

230 (38.1)

65.6

62.0

1.12 (1.04–1.20)

3.0E−3

  1. HR: hazard ratio, CI: confidence interval, mdNLR: methylation-derived neutrophil to lymphocyte ratio
  2. Stratification was used on sex and BCG treatment status for proportional assumption
  3. $The model controlling for age, sex, tumor grade, smoking status, BCG treatment status, and mdNLR
  4. *Winsorization was used on the top 2% values for fitting linearity assumption
  5. #Initial recurrence or the death whose cause was unknown