Fig. 4

Performance of the 5hmC-fragmentation integrated model for lung cancer detection. A T-SNE plot of paired 5hmC features and fragmentation profiles data, based on the 85 features including the 37 5hmC biomarkers and 48 fragmentation areas. B Performance of the 5hmC-fragmentation integrated model in the training set, validation set and external validation set. C Boxplot of wd-score deriving from the integrated model for the lung cancer samples and the healthy controls (training set P value = 5.41E−40, validation set P value = 1.91E−15). D Boxplot of the wd-scores from the integrated model for stage I–IV lung cancer samples.*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 1e−5, Wilcoxon test