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Fig. 4 | Clinical Epigenetics

Fig. 4

From: A deep learning model for early risk prediction of heart failure with preserved ejection fraction by DNA methylation profiles combined with clinical features

Fig. 4

Gene ontology categories and pathways analysis of DNA methylation loci in HFmeRisk model. a Gene ontology enrichment of CpG loci (MF molecular function, CC cellular component, BP biological process). b KEGG pathways enrichment of CpG loci. In a and b, the red line is where the − log10 P values = 1.3 (P = 0.05). c Using ReactomePA, pathways are sorted based on the fold enrichment (x-axis). Fold enrichment was defined as the ratio of two proportions, the gene ratio and the BG ratio; Gene ratio indicates the number of genes annotated to a pathway within the specific list of differential genes among the major contributors that are included in the database; BG ratio denotes the total number of genes in the gene set and the total number of all genes in any gene set. The size of the dot indicates the number of genes that are annotated to the pathway, and the color of the dot indicates the P values. From these values, the raw “P values” is calculated using a hypergeometric test. d Correspondence between genes and pathways in c

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Clinical Epigenetics

ISSN: 1868-7083

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