Table 2 Summary table of candidate gene studies assessing DNA methylation in the Igf2/H19 locus
Publication | Locus | Tissue | Change in methylation from PAE |
|---|---|---|---|
Marjonen (2017) | H19 DMR (C6), H19 ICR | Placenta | Hypomethylation (nominal P-value only) |
Masemola | H19 ICR (C6) | Blood, buccal | Hypomethylation |
Marjonen (2018) | H19 ICR (C1 and C2), IGF2 DMR1 | Placenta, embryo | No change |
Haycock | H19 ICR (C1 and C2) | Placenta, embryo | Hypomethylation in placenta, no change in embryo |
Zhou | H19 DMR, IGF2 DMR0, 1,2 | Heart, brain, placenta | Hypomethylation at Igf2 DMR1, Igf2 DMR2, and H19, no change at Igf2 DMR0 |
Downing | IGF2 DMR1 | Placenta, embryo | Hypomethylation |
Stouder | H19 ICR | Sperm, brain, muscle, liver, tail | Hypomethylation in CTCF12 (F1) and all six sites (F2) in sperm, no change in other tissues (F1) |