Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)

Table 2 Association between methylation risk scores and atherosclerosis measures in GENOA African-Americans

Outcome	Methylation risk score	Model 1			Model 2			Model 3
Outcome	Methylation risk score	Beta	SE	P	Beta	SE	P	Beta	SE	P
Coronary artery calcification score (CAC)^a	MRS_CAC	0.262	0.146	0.074	0.153	0.173	0.295	0.138	0.139	0.318
Coronary artery calcification score (CAC)^a	MRS_carotid	0.700	0.155	8.66 × 10^–6	0.425	0.199	0.033	0.411	0.191	0.032
Abdominal aorta calcification score (AAC)^a	MRS_CAC	0.364	0.160	0.023	0.175	0.154	0.258	0.173	0.151	0.252
Abdominal aorta calcification score (AAC)^a	MRS_carotid	1.046	0.167	1.10 × 10^–9	0.580	0.211	0.006	0.605	0.208	0.004
Ankle–brachial index (ABI)	MRS_CAC	0.013	0.006	0.025	0.015	0.006	0.008	0.016	0.006	0.006
Ankle–brachial index (ABI)	MRS_carotid	− 0.014	0.006	0.021	− 0.009	0.008	0.275	− 0.007	0.008	0.400
Multi-site atherosclerosis score	MRS_CAC	0.317	0.170	0.064	0.145	0.165	0.382	0.127	0.162	0.433
Multi-site atherosclerosis score	MRS_carotid	1.165	0.177	1.65 × 10^–10	0.718	0.225	0.002	0.691	0.223	0.002

Model 1 is adjusted for age, sex, time between measures, and the first 4 genetic principal components
Model 2 is adjusted for Model 1 covariates and smoking status
Model 3 is adjusted for Model 2 covariates, hypertension status, diabetes status, body mass index, and total cholesterol levels adjusted for statin use
Beta is the change in the atherosclerosis measure associated with a 1 unit increase in the MRS
P values significant after Bonferroni correction (P < 0.025) are shown in bold font
^aCoronary artery and abdominal aorta calcification scores were transformed as ln[(CAC + 1)] and ln[(AAC + 1)]

ISSN: 1868-7083