Skip to main content

Table 1 Descriptive characteristics of GENOA African-Americans

From: Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)

Characteristicsa

Overall (N = 391)

Females (%)

297 (76.0%)

Age at Phase I (years)

56.0 ± 9.0

Age at Phase III (years)

68.0 ± 8.4

Cardiovascular risk factors at Phase I

 

Smoking status

 

 Never (%)

241 (61.6%)

 Former (%)

93 (23.8%)

 Current (%)

57 (14.6%)

Body mass index (kg/m2)

31.4 ± 6.2

Hypertension

249 (63.7%)

Type 2 diabetes

63 (16.1%)

Total cholesterolb (mg/dl)

208.56 ± 50.4

Low-density lipoprotein cholesterolc (mg/dl)

121.8 (42.8)

Statin use (%)

18 (4.6%)

Atherosclerosis measures at Phase III

 

Coronary artery calcification score, median (IQR)

18.7 (0–195.7)

Abdominal aorta calcification score, median (IQR)

500.8 (18.9–1800.5)

Ankle–brachial index, median (range)d

0.985 (0.474–1.274)

Multi-site atherosclerosis score, median (IQR) (range 0–12)

5 (2–7)

Methylation risk scores at Phase I

 

MRSCACe

0.92 ± 0.85

MRScarotid

− 3.52 ± 0.81

DNAm age measures at Phase I

 

HorvathAge (years)

52.8 ± 8.9

HannumAge (years)

46.2 ± 9.5

PhenoAge (years)

42.7 ± 11.5

GrimAge (years)

52.8 ± 7.9

  1. IQR interquartile range, DNAm DNA methylation
  2. aMeans ± standard deviation
  3. bAdjusted for statin use as total cholesterol/0.8
  4. cCalculated using the Friedewald formula for participants with triglycerides < 400 mg/dl (N = 386)
  5. dMeasured at Phase II (mean: 5.2 ± 1.3 years from Phase I)
  6. eN = 390, after removing one outlier beyond 5 standard deviation units from the mean