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Fig. 4 | Clinical Epigenetics

Fig. 4

From: HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer

Fig. 4

Source of patient gene expression data: TCGA. Source of gene set enrichment profiles: MSigDB

High HDAC8 expression correlates with repression of the epithelial differentiation program in BLBC patients. A Plot depicting all C2 curated gene sets (MSigDB) enriched in GSEA analyses of HDAC8high- and HDAC8low-expressing BLBC patients. B Representative gene set enrichment profiles of the EMT and MET transcription programs in HDAC8low- and HDAC8high-BLBC patients. NES: Normalized Enrichment Score. C Gene set enrichment profiles of the MET-TFs GATA3 and RORA whose gene targets are particularly expressed in HDAC8low-BLBC patients. D–E Scatter plot showing the anti-correlation of the MET-TFs with HDAC8 in primary tumors (D) and brain metastases (E) of TNBC patients. Data were retrieved from the R2 platform. F Kaplan–Meier plots showing the relapse-free survival probability of HDAC8-, ELF5-, GATA3- and RORA-expressing BLBC patients receiving only chemotherapy as a treatment option (Log-rank test). Data were retrieved from the KM plotter. A–C

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